Speaker Articles

Take a look at what our invited speakers have published recently and chat with them about their work in Ghent at our symposium.

Alberto Bardelli
A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

Lewis Cantley
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Peter Carmeliet
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

Nika Danial
Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

Richard Gilbertson
Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

Cross-Species Genomics Identifies TAF12NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes

Johanna Joyce
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.

Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.

Jan Korbel
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

David Lyden
Tumour exosome integrins determine organotropic metastasis.

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.

Elaine Mardis
Germline Mutations in Predisposition Genes in Pediatric Cancer.

Miriam Merad
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

Angela Nieto
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.

Caroline Robert
Pembrolizumab versus Ipilimumab in Advanced Melanoma.

Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive >melanoma (COMBI-v): results of a phase 3, open-label, randomised trial.

Charles W. M. Roberts
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.

Vulnerabilities of mutant SWI/SNF complexes in cancer.

Ton Schumacher
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

The Branching Point in Erythro-Myeloid Differentiation

Padmanee Sharma
Monitoring immune responses in the tumor microenvironment.

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

Louis Staudt
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma

Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma.

Charles Swanton
Clinical Implications of Genomic Discoveries in Lung Cancer.

Metastasis as an evolutionary process.

SnapShot: Renal Cell Carcinoma.

Andreas Trumpp
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

Karen Vousden
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation

Laurence Zitvogel
Microbiome and Anticancer Immunosurveillance

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.

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